Počet záznamů: 1

Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats

  1. 1.
    0365731 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Klevstig, M. J. - Marková, I. - Burianová, J. - Kazdová, L. - Pravenec, Michal - Nováková, O. - Novák, F.
    Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats.
    Molecular and Cellular Biochemistry. Roč. 357, 1-2 (2011), s. 163-169 ISSN 0300-8177
    Grant CEP: GA ČR(CZ) GD305/08/H037; GA MŠk(CZ) ME08006
    Grant ostatní:Univerzita Karlova(CZ) SVV33779266
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: CD36 * novel PKC * spontaneously hypertensive rat * insulin resistance
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.057, rok: 2011

    Searching for a possible role of novel protein kinase C (nPKC) in heart with disrupted energy balance, we compared the insulin-resistant spontaneously hypertensive rats (SHR), which carry a nonfunctional variant of the fatty acid transporter FAT/CD36, with the less insulin-resistant congenic strain SHR-4 that is genetically identical except for a segment on chromosome 4 including a wild-type gene for a functional FAT/CD36. Our results demonstrate that reduced insulin resistance in SHR-4 rats is associated with the insulin signaling pathway involving nPKCs
    Trvalý link: http://hdl.handle.net/11104/0200903