Počet záznamů: 1

Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion

  1. 1.
    0365285 - FGU-C 2012 RIV NL eng J - Článek v odborném periodiku
    Brejchová, Jana - Sýkora, Jan - Dlouhá, Kateřina - Roubalová, Lenka - Ostašov, Pavel - Vošahlíková, Miroslava - Hof, Martin - Svoboda, Petr
    Fluorescence spectroscopy studies of HEK293 cells expressing DOR-Gi1alfa fusion protein; the effect of cholesterol depletion.
    Biochimica Et Biophysica Acta-Biomembranes. Roč. 1808, č. 12 (2011), s. 2819-2829 ISSN 0005-2736
    Grant CEP: GA MŠk(CZ) LC06063; GA MŠk(CZ) LC554; GA ČR(CZ) GD305/08/H037
    Grant ostatní: GA ČR(CZ) GAP208/10/1090
    Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z40400503
    Klíčová slova: plasma membrane * cholesterol depletion * fluorescence spectroscopy * hydrophobic membrane interior * delta-opioid receptor (DOR), * G protein
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.990, rok: 2011

    Effect of cholesterol on the organization of plasma membranes and G-protein activation. Cholesterol depletion increases membrane fluidity and mobility of plasma membranes. Cholesterol depletion does not alter the agonist binding site of delta-opioid receptor (DOR), but decreases the ability of DOR agonist to activate G proteins
    Trvalý link: http://hdl.handle.net/11104/0200565