Počet záznamů: 1

Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates

  1. 1.
    0365267 - UEB-Q 2012 RIV US eng J - Článek v odborném periodiku
    Svobodová, Hana - Nonappa, J. - Wimmer, Zdeněk - Kolehmainen, E.
    Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates.
    Journal of Colloid and Interface Science. Roč. 361, č. 2 (2011), s. 587-593 ISSN 0021-9797
    Grant CEP: GA MŠk 2B06024; GA MŠk(CZ) OC10001
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Stigmasterol * Amino acid * LMOG
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.070, rok: 2011

    An efficient synthesis of three novel stigmasterol-amino acid (glycine, L-leucine and L-phenylalanine) conjugates as stimuli responsive gelators is reported. The gelation properties of the prepared compounds were investigated in a variety of organic as well as aqueous solvents. The most striking finding of our investigation was that the hydrochloride salts of the prepared conjugates acted as gelators, whereas the neutral conjugates were either non-gelators or formed only a weak gel in anisole. The hydrochloride salts of stigmasteryl glycinate and L-Ieucinate form gels in n-alcohols (n = 4-10) and in ethane-1,2-diol, and that of stigmasteryl L-phenylalaninate forms gels in aromatic solvents and in tetrachloromethane. These unique properties of the gelators were explored to prepare stimuli responsive, "acid-base" triggered reversible sol-gel transitions. The gelators and their gels were characterized by liquid and solid-state NMR as well as FT-IR.
    Trvalý link: http://hdl.handle.net/11104/0200550