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The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure

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    0365117 - UMG-J 2012 RIV AU eng J - Článek v odborném periodiku
    Rohoušová, I. - Hostomská, J. - Vlková, M. - Kobets, Tetyana - Lipoldová, Marie - Volf, P.
    The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure.
    International Journal for Parasitology. Roč. 41, č. 5 (2011), s. 481-485 ISSN 0020-7519
    Grant CEP: GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: Phlebotomus duboscqi * Leishmania major * anti-saliva IgG
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.393, rok: 2011

    Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva.
    Trvalý link: http://hdl.handle.net/11104/0200435
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