Počet záznamů: 1

How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels

  1. 1.
    0365082 - FGU-C 2012 RIV GB eng J - Článek v odborném periodiku
    Kochová, P. - Cimrman, R. - Janáček, Jiří - Witter, K. - Tonar, Z.
    How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels.
    Journal of Theoretical Biology. Roč. 286, - (2011), s. 67-78 ISSN 0022-5193
    Grant ostatní:GA ČR(CZ) GA106/09/0740; GA ČR(CZ) GP106/09/P226
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: rose of directions * preferential directions * chi-square test * length density * python
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 2.208, rok: 2011

    In our study, we present a novel p(chi2) (chi-square) method for evaluating the anisotropy of line systems that involves comparing the observed length densities of lines with the discrete uniform distribution of an isotropic line system with the chi2-test. Using this method in our open source software, we determined the rose of directions, preferential directions and level of anisotropy of linear systems representing the microscopic blood vessels in samples of various regions from human brains (cortex, subcortical gray matter and white matter). The novel method was compared with two other methods used for anisotropy quantification (ellipsoidal and fractional anisotropy). All three methods detected different levels of anisotropy of blood microvessels in human brain. The microvascular bed in the cortex was closer to an isotropic network, while the microvessels supplying the white matter appeared to be an anisotropic and direction-sensitive system
    Trvalý link: http://hdl.handle.net/11104/0200416