Počet záznamů: 1

Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments

  1. 1.
    0365079 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Wilhelm, J. - Ivica, J. - Kagan, Dmytro - Svoboda, Petr
    Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments.
    Molecular and Cellular Biochemistry. Roč. 347, 1-2 (2011), s. 157-162 ISSN 0300-8177
    Grant CEP: GA MŠk(CZ) LC554; GA AV ČR(CZ) IAA500110606
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: brain * early development * lipofuscin-like pigments * fluorescence * rat
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.057, rok: 2011

    The increased generation of free radicals results in the formation of fluorescent end-products of lipid peroxidation, lipofuscin-like pigments (LFPs). The authors observed that LFPs are generated in rat brain after a normal birth during 5 postnatal days. Maximum LFP concentration is achieved on the postnatal day 2. Starting from postnatal day 10, LFP concentration returns to prenatal values. A new rise in LFP concentration is observed at 3 months of age. This is associated with the beginning of the aging process. The authors suggest that LFPs are formed after respiratory burst of microglia phagocytosing apoptotic cells
    Trvalý link: http://hdl.handle.net/11104/0200414