Počet záznamů: 1

The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole

  1. 1.
    0365057 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Mesárošová, M. - Valovičová, Z. - Srančíková, A. - Krajčovičová, Z. - Milcová, Alena - Sokolová, Romana - Schmuczerová, Jana - Topinka, Jan - Gábelová, A.
    The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole.
    Toxicology and Applied Pharmacology. Roč. 255, č. 3 (2011), s. 307-315 ISSN 0041-008X
    Grant CEP: GA MŠk 2B08005
    Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z40400503; CEZ:AV0Z50040507
    Klíčová slova: cytochrome P4503A4 * 7H-dibenzo[c,g]carbazole * Hprt gene mutations
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 4.447, rok: 2011

    The environmental pollutant 7H-dibenzo[c,g]carbazole (DBC) and its derivative, 5,9-dimethylDBC (DiMeDBC), produced significant and dose-dependent levels of micronuclei followed by a substantial increase in the frequency of apoptotic cells in the V79MZh3A4 cell line stably expressing the human cytochrome P450 (hCYP) 3A4. In contrast, neither micronuclei nor apoptosis were found in cells exposed to the sarcomagenic carcinogen, N-methylDBC (N-MeDBC). Based on our results, we suggest that hCYP3A4 is involved in the metabolism of DBC and its tissue-specific derivatives. While hCYP3A4 probably plays an important role in biotransformation of the liver carcinogens, DBC and DiMeDBC, it might only have a marginal function in N-MeDBC metabolism.
    Trvalý link: http://hdl.handle.net/11104/0200393