Počet záznamů: 1
Fibrinogen-related proteins in ixodid ticks
0364780 - BC-A 2012 RIV GB eng J - Článek v odborném periodiku
Štěrba, J. - Dupejová, J. - Fišer, M. - Vancová, Marie - Grubhoffer, Libor
Fibrinogen-related proteins in ixodid ticks.
Parasites & Vectors. Roč. 4, - (2011), e127 ISSN 1756-3305
Grant CEP: GA MŠk(CZ) LC06009; GA AV ČR KJB600960906; GA ČR GA206/09/1782
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: AMERICAN DOG TICK * INNATE IMMUNITY * DORIN-M * RHIPICEPHALUS-APPENDICULATUS * MOLECULAR CHARACTERIZATION * DERMACENTOR-VARIABILIS * ORNITHODOROS-MOUBATA * LECTINS * HEMOLYMPH * BINDING
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 2.937, rok: 2011
Fibrinogen-related proteins with lectin activity are believed to be part of the tick innate immune system. Some of them were detected in high abundance in the haemolymph of ixodid ticks Dermacentor marginatus, Rhipicephalus appendiculatus, R. pulchellus, and R. sanguineus. These proteins were recognised by sera directed against the tick lectin Dorin M and the haemagglutination activity of the ticks R. appendiculatus and D. marginatus. The fibrinogen-related proteins were shown to be glycosylated and they were localised in salivary glands, midguts, and haemocytes of D. marginatus. The detected proteins have potential as targets for anti-tick vaccines and as antimicrobial proteins in pharmacology.
Trvalý link: http://hdl.handle.net/11104/0200167