Počet záznamů: 1

Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

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    0364747 - BC-A 2012 RIV DE eng M - Část monografie knihy
    Kašný, M. - Mikeš, L. - Dolečková, K. - Hampl, V. - Dvořák, Jan - Novotný, M. - Horák, P.
    Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis.
    Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms. BERLIN: SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197, 2011 - (Robinson, M.; Dalton, J.), s. 136-154. Advances in Experimental Medicine and Biology, 712. ISBN 978-1-4419-8413-5
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: Trichobilharzia * trematode * Schistosoma * Fasciola * peptidase * cercarial elastase * cathepsin * hydrolysis * blood digestion * tissue migration * biochemical characterization * phylogeny * function
    Kód oboru RIV: GJ - Choroby a škůdci zvířat, veterinární medicína

    Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.
    Trvalý link: http://hdl.handle.net/11104/0006564