Počet záznamů: 1

Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells

  1. 1.
    0364720 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Vagnerová, Karla - Loukotová, Jana - Ergang, Peter - Musílková, Jana - Mikšík, Ivan - Pácha, Jiří
    Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.
    Steroids. Roč. 76, č. 6 (2011), s. 577-581 ISSN 0039-128X
    Grant CEP: GA ČR(CZ) GAP303/10/0969
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: 11beta-hydroxysteroid dehydrogenase * thiazolidinediones
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 2.829, rok: 2011

    The study demonstrates that activation of PPARgamma in vascular smooth muscle cells up-regulates vascular 11HSD1and thus reactivates 11-oxo metabolites to biologically active glucocorticoids. The data provide one of the possible explanations for PPARgamma-agonist’s effects on the cardiovascular system
    Trvalý link: http://hdl.handle.net/11104/0200126