Počet záznamů: 1

Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling

  1. 1.
    0364583 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Charles, C. - Hovořáková, Mária - Ahn, Y. - Lyons, D. B. - Marangoni, P. - Churavá, Svatava - Biehs, B. - Jheon, A. - Lesot, H. - Balooch, G. - Krumlauf, R. - Viriot, L. - Peterková, Renata - Klein, O. D.
    Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling.
    Development. Roč. 138, č. 18 (2011), s. 4063-4073 ISSN 0950-1991
    Grant CEP: GA ČR GA304/09/1579; GA ČR GA304/07/0223
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: FGF signaling * Sprouty genes * Incisor
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 6.596, rok: 2011

    In Sprouty loss of function mutants, splitting of gene expression domains and reduced apoptosis was associated with subdivision of the incisor primordium and a multiplication of its stem cell-containing regions. The changes in Sprouty gene dosage led to a graded change in incisor number, with progressive decreases in Sprouty dosage leading to increasing numbers of teeth. The independent development of two incisors in mutants with large decreases in Sprouty dosage mimicked the likely condition of rodent ancestors. Our findings indicate that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway.
    Trvalý link: http://hdl.handle.net/11104/0200032