Počet záznamů: 1

Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids

  1. 1.
    0364489 - FGU-C 2012 RIV DE eng J - Článek v odborném periodiku
    Flachs, Pavel - Rühl, R. - Hensler, Michal - Janovská, Petra - Zouhar, Petr - Kůs, Vladimír - Macek Jílková, Zuzana - Papp, E. - Kuda, Ondřej - Svobodová, Michaela - Rossmeisl, Martin - Tsenov, Grygoriy - Mohamed-Ali, V. - Kopecký, Jan
    Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids.
    Diabetologia. Roč. 54, č. 10 (2011), s. 2626-2638 ISSN 0012-186X
    Grant CEP: GA MŠk(CZ) 1M0520; GA ČR(CZ) GA303/08/0664
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: 15-Deoxy-Delta(12,15)-prostaglandin J(2) * DHA * EPA * fish oil * white adipose tissue * metabolic syndrome
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 6.814, rok: 2011

    White adipose tissue plays an active role in the amelioration of obesity and the improvement of glucose homeostasis by combining LC n-3 PUFA intake and calorie restriction in mice fed high-fat diet. Specifically in the epididymal fat in the abdomen, but not in other fat depots, synergistic induction of mitochondrial oxidative capacity and lipid catabolism was observed, resulting in increased oxidation of metabolic fuels in the absence of mitochondrial uncoupling, while low-grade inflammation was suppressed, reflecting changes in tissue levels of anti-inflammatory lipid mediators, namely 15-Deoxy-∆12,15-prostaglandin J2 and protectin D1
    Trvalý link: http://hdl.handle.net/11104/0199963