Počet záznamů: 1

LC-ESI-MS-MS Method for Monitoring Dopamine, Serotonin and Their Metabolites in Brain Tissue

  1. 1.
    0364479 - FGU-C 2012 RIV DE eng J - Článek v odborném periodiku
    Najmanová, V. - Rambousek, Lukáš - Syslová, K. - Bubeníková, V. - Šlamberová, R. - Valeš, Karel - Kačer, P.
    LC-ESI-MS-MS Method for Monitoring Dopamine, Serotonin and Their Metabolites in Brain Tissue.
    Chromatographia. Roč. 73, Suppl.1 (2011), s. 143-149 ISSN 0009-5893
    Grant CEP: GA MZd(CZ) NS10365
    Grant ostatní: GA ČR(CZ) GAP303/10/0580; GA ČR(CZ) GA305/09/0126; GA ČR(CZ) GD203/08/H032
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: dopamine * microdialyses * liquid chromatography * tandem mass spectrometry
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 1.195, rok: 2011

    The reaction monitoring mode was selected for its extremely high degree of selectivity and the stable-isotope-dilution assay for its high precision of quantification. It was proven that the developed assay could be applied to both a simultaneous analysis of all four substrates (dopamine, homovanillic acid, 3-methoxytyramine and 3,4-dihydroxyphenylacetic acid) in microdialysis samples acquired from the rat brain and the monitoring of their slight concentration changes on a picogram level over time following methamphetamine stimulus
    Trvalý link: http://hdl.handle.net/11104/0199957