Počet záznamů: 1

Poly(ethylene oxide) layers grafted to dopamine-melanin anchoring layer: stability and resistance to protein adsorption

  1. 1.
    0364383 - UMCH-V 2012 RIV US eng J - Článek v odborném periodiku
    Pop-Georgievski, Ognen - Popelka, Štěpán - Houska, Milan - Chvostová, Dagmar - Proks, Vladimír - Rypáček, František
    Poly(ethylene oxide) layers grafted to dopamine-melanin anchoring layer: stability and resistance to protein adsorption.
    Biomacromolecules. Roč. 12, č. 9 (2011), s. 3232-3242 ISSN 1525-7797
    Grant CEP: GA AV ČR KJB400500904; GA ČR GAP108/11/1857; GA ČR GPP207/10/P569
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z10100522
    Klíčová slova: dopamine-melanin * polydopamine * poly(ethylene oxide)
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 5.479, rok: 2011

    In this study, we propose substrate-independent modification for creating a protein-repellent surface based on dopamine-melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-melanin layer can be formed on literally any substrate and could serve as the anchoring layer for subsequent grafting of PEO chains. Grafting of PEO from melt in a temperature range 70–110 °C produces densely packed PEO layers showing exceptionally low protein adsorption when exposed to the whole blood serum or plasma. The PEO layers prepared from melt at 110 °C retained the protein repellent properties for as long as 10 days after their exposure to physiological-like conditions. The PEO-dopamine-melanin modification represents a simple and universal surface modification method for the preparation of protein repellent surfaces that could serve as a nonfouling background in various applications, such as optical biosensors and tissue engineering.
    Trvalý link: http://hdl.handle.net/11104/0006551