Počet záznamů: 1

Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery

  1. 1.
    0364301 - FGU-C 2012 RIV NL eng J - Článek v odborném periodiku
    Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
    Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery.
    European Journal of Pharmacology. Roč. 667, 1-3 (2011), s. 265-270 ISSN 0014-2999
    Grant CEP: GA ČR(CZ) GA305/09/0336; GA AV ČR(CZ) IAA500110902
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: EDCF * SHR * norepinephrine * L-NNA * indomethacin
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 2.516, rok: 2011

    Endothelium-dependent contraction elicited by high concentrations of acetylcholine was described in hypertensive as well as in aged normotensive rats. The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown. We aimed to compare EDCF participation to norepinephrine-induced arterial contraction in spontaneously hypertensive rats (SHR) and aged normotensive Wistar-Kyoto (WKY) rats. We conclude that EDCF contribution to norepinephrine-induced contraction of conduit arteries is similarly enhanced in adult hypertensive and aged normotensive rats
    Trvalý link: http://hdl.handle.net/11104/0199821