Počet záznamů: 1

Biomarkers of exposure and effect – interpretation for human risk

  1. 1.
    0363581 - UEM-P 2012 RIV NL eng J - Článek v odborném periodiku
    Šrám, Radim - Binková, B. - Beskid, Olena - Milcová, Alena - Rössner, P. - Rössner ml., Pavel - Rössnerová, Andrea - Solanský, I. - Topinka, Jan
    Biomarkers of exposure and effect – interpretation for human risk.
    Air Quality, Atmosphere and Health (AQAH). Roč. 4, č. 3 (2011), s. 161-167 ISSN 1873-9318
    Grant CEP: GA MŽP SL/5/160/05; GA MŽP(CZ) SP/1B3/8/08
    Grant ostatní: FP6(XE) SSPE-CT-2005-044232 project ENVIRISK; FP6(XE) 18385-2 project INTARESE
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: personal monitoring * benzo[a]pyrene * carcinogenic polycyclic aromatic hydrocarbons
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví

    The effect of exposure to carcinogenic PAHs adsorbed onto respirable air particles on DNA adducts and chromosomal aberrations was repeatedly studied in groups of policemen and bus drivers from Prague, Czech Republic. Personal exposure was evaluated using personal samplers during working shifts. DNA adducts were analyzed in lymphocytes by the 32P-postlabeling assay and chromosomal aberrations by conventional cytogenetic analysis and by fluorescent in situ hybridization (FISH). The studies suggest that the environmental exposure of nonsmokers to concentrations higher than 1 ng B[a]P/m3 represents a risk to DNA damage, as indicated by an increase in DNA adducts and in the genomic frequency of translocations determined by FISH.
    Trvalý link: http://hdl.handle.net/11104/0199348