Počet záznamů: 1

Regioselective alcoholysis of silybin A and B acetates with lipases

  1. 1.
    0363054 - MBU-M 2012 RIV NL eng J - Článek v odborném periodiku
    Purchartová, Kateřina - Marhol, Petr - Gažák, Radek - Monti, D. - Riva, S. - Kuzma, Marek - Křen, Vladimír
    Regioselective alcoholysis of silybin A and B acetates with lipases.
    Journal of Molecular Catalysis B-Enzymatic. Roč. 71, 3-4 (2011), s. 119-123 ISSN 1381-1177
    Grant CEP: GA MŠk OC09045; GA MŠk(CZ) ME10027; GA ČR(CZ) GAP301/11/0767
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Silybin B * Silibinin * Silymarin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.735, rok: 2011

    Large screening identified lipase AK to be capable of the selective deacetylation of pentaacetyl silybins A and B to yield 3,5,20,23-tetra-O-acetyl-silybins A and B, and 3,20,23-tri-O-acetyl-silybins A and B, respectively. Deacetylation occurred at phenolic OH groups, only. These new compounds prepared from the optically pure silybins can serve as new stereochemically pure synthons for selective silybin modifications
    Trvalý link: http://hdl.handle.net/11104/0199161