Počet záznamů: 1

Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis

  1. 1.
    0361620 - MBU-M 2012 RIV GB eng J - Článek v odborném periodiku
    Kverka, Miloslav - Rossmann, Pavel - Tlaskalová-Hogenová, Helena - Klimešová, Klára - Jharap, B. - de Boer, N. - Vos, R. M. - van Bodegraven, A.A. - Lukáš, M. - Mulder, Ch.J.
    Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis.
    BMC Gastroenterology. Roč. 11, č. 1 (2011), s. 1-9 ISSN 1471-230X
    Grant CEP: GA AV ČR KJB500200904; GA ČR GD310/08/H077; GA MŠk 2B06155
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: INFLAMMATORY-BOWEL-DISEASE * NODULAR REGENERATIVE HYPERPLASIA * LOW-DOSE 6-THIOGUANINE
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 2.422, rok: 2011

    Background: Oral thiopurines are effective and widely used in treatment of inflammatory bowel disease (IBD) in humans, although their use is limited due the development of adverse events. Here, we examine the efficacy and toxicity of oral treatment with 6-tioguanine (6-TG) and azathioprine (AZA) in a murine model of IBD
    Trvalý link: http://hdl.handle.net/11104/0006519