Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases

0361618 - MBÚ 2012 RIV CZ eng J - Článek v odborném periodiku
Drastich, P. - Frolová-Břízová, Lenka - Zanvit, P. - Špičák, J. - Tlaskalová-Hogenová, Helena
Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel diseases.
Folia Microbiologica. Roč. 56, č. 3 (2011), 185-190. ISSN 0015-5632. E-ISSN 1874-9356
Grant CEP: GA AV ČR 1QS500200572; GA ČR GA305/08/0535; GA ČR GD310/08/H077; GA MŠMT 2B06155
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: NECROSIS-FACTOR-ALPHA * ULCERATIVE-COLITIS * CROHNS-DISEASE
Kód oboru RIV: EC - Imunologie
Impakt faktor: 0.677, rok: 2011

Interleukin-6 (IL-6) plays an important role in regulation of intestinal inflammatory processes in inflammatory bowel disease (IBD). The levels of IL-6 in media from cultured biopsy samples were determined by ELISA in 14 Crohn’s disease (CD) patients, 17 patients with ulcerative colitis (UC), and 24 healthy controls in terminal ileum, cecum, and rectum. Results were confirmed by measuring mRNA expression in selected patients. In CD patients, there were increased levels of IL-6 (expressed in picograms per milligram of biopsy tissue mass) in terminal ileum compared with controls
Trvalý link: http://hdl.handle.net/11104/0198895