Počet záznamů: 1

A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates

  1. 1.
    0360949 - UOCHB-X 2012 RIV GB eng J - Článek v odborném periodiku
    Beier, Petr - Opekar, Stanislav - Zibinsky, M. - Bychinskaya, I. - Prakash, G. K. S.
    A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates.
    Organic & Biomolecular Chemistry. Roč. 9, č. 11 (2011), s. 4035-4038 ISSN 1477-0520
    Grant CEP: GA ČR GP203/08/P310
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: fluorine * phosphonate * alkylation
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.696, rok: 2011

    A new route to alpha-alkyl-alpha-fluoromethylenebisphosphonates (2) has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either cesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important alpha-alkyl-alpha-fluoromethylenebisphosphonic acid (3), while alkoxide–induced carbon–phosphorus bond cleavage of 2 gave alfa-fluorophosphonates (4), which are useful synthons in organic synthesis.
    Trvalý link: http://hdl.handle.net/11104/0198381