Počet záznamů: 1

Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine

  1. 1.
    0360867 - MBU-M 2012 RIV DE eng J - Článek v odborném periodiku
    Biswas, A. - Wilmanski, J. - Forsman, H. - Hrnčíř, Tomáš - Hao, L. - Tlaskalová-Hogenová, Helena - Kobayashi, K.
    Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.
    European Journal of Immunology. Roč. 41, č. 1 (2011), s. 182-194 ISSN 0014-2980
    Grant CEP: GA ČR GP310/09/P182
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Caspase-1 * Colitis * IL-10
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 5.103, rok: 2011

    A healthy intestinal tract is characterized by controlled homeostasis due to the balanced interaction between commensal bacteria and the host mucosal immune system. Human and animal model studies have supported the hypothesis that breakdown of this homeostasis may underlie the pathogenesis of inflammatory bowel diseases. However, it is not well understood how intestinal microflora stimulate the intestinal mucosal immune system and how such activation is regulated
    Trvalý link: http://hdl.handle.net/11104/0198322