SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

0360813 - ÚOCHB 2012 RIV GB eng J - Článek v odborném periodiku
Šála, Michal - De Palma, A. M. - Hřebabecký, Hubert - Dejmek, Milan - Dračínský, Martin - Leyssen, P. - Neyts, J. - Mertlíková-Kaiserová, Helena - Nencka, Radim
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 21, č. 14 (2011), s. 4271-4275. ISSN 0960-894X. E-ISSN 1464-3405
Grant CEP: GA MŠMT 1M0508; GA ČR GAP303/11/1297
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: coxsackievirus * norbornane * picornaviruses
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.554, rok: 2011

Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series.
Trvalý link: http://hdl.handle.net/11104/0198276