Počet záznamů: 1

Rapid changes in gene expression: DNA determinants of promoter regulation by the

  1. 1.
    0360790 - MBU-M 2012 RIV GB eng J - Článek v odborném periodiku
    Sojka, Luděk - Kouba, Tomáš - Barvík, I. - Šanderová, Hana - Maderová, Zdeňka - Jonák, Jiří - Krásný, Libor
    Rapid changes in gene expression: DNA determinants of promoter regulation by the.
    Nucleic Acids Research. Roč. 39, č. 11 (2011), s. 4598-4611 ISSN 0305-1048
    Grant CEP: GA MŠk 2B06065
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: RIBOSOMAL-RNA TRANSCRIPTION * ILV-LEU OPERON * CHAIN AMINO-ACIDS
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 8.026, rok: 2011

    In bacteria, rapid changes in gene expression can be achieved by affecting the activity of RNA polymerase with small molecule effectors during transcription initiation. An important small molecule effector is the initiating nucleoside triphosphate (iNTP). At some promoters, an increasing iNTP concentration stimulates promoter activity, while a decreasing concentration has the opposite effect. Ribosomal RNA (rRNA) promoters from Grampositive Bacillus subtilis are regulated by the concentration of their iNTP. Yet, the sequences of these promoters do not emulate the sequence characteristics of [iNTP]-regulated rRNA promoters of Gram-negative Escherichia coli. Here, we identified the 30-promoter region, corresponding to the transcription bubble, as key for B. subtilis rRNA promoter regulation via the concentration of the iNTP
    Trvalý link: http://hdl.handle.net/11104/0198257