Počet záznamů: 1

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

  1. 1.
    0360740 - UOCHB-X 2012 RIV GB eng J - Článek v odborném periodiku
    Baszczyňski, Ondřej - Jansa, Petr - Dračínský, Martin - Klepetářová, Blanka - Holý, Antonín - Votruba, Ivan - De Clercq, E. - Balzarini, J. - Janeba, Zlatko
    Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
    Bioorganic & Medicinal Chemistry. Roč. 19, č. 7 (2011), s. 2114-2124 ISSN 0968-0896
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * purines * FPMP * antiviral * N6-Methyl-AMP aminohydrolase
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.921, rok: 2011

    An efficient method for the synthesis of N9-[3-fluoro-2-(phosphonomethoxy)propyl] (FPMP) derivatives of purine bases has been developed. Several FPMPDAP derivatives had a moderate antiretroviral activity.
    Trvalý link: http://hdl.handle.net/11104/0198222