HVRII of mtDNA in Cord Blood Cells of Newborn Children and in Their Saliva 10 Years Later

0360462 - ÚEM 2012 RIV CZ eng J - Článek v odborném periodiku
Schmuczerová, Jana - Töröková, P. - Kujanová, M. - Čechová, H. - Topinka, Jan - Dostál, Miroslav - Šrám, Radim - Brdička, R.
HVRII of mtDNA in Cord Blood Cells of Newborn Children and in Their Saliva 10 Years Later.
Folia Biologica. Roč. 56, č. 1 (2011), s. 26-29. ISSN 0015-5500. E-ISSN 0015-5500
Grant CEP: GA MŽP SL/5/160/05
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: mitochondrial DNA * cord blood * saliva
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 1.151, rok: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0360462_01.pdf

Comparison of hypervariable region II nucleotide sequences of mitochondrial DNA obtained from cord blood cells and saliva cells of the same individual at birth and after ten years showed a few differences at the co-called mutation hot spots (three transitions and three indels within the C-tract). The personal identity of samples was proved by short tandem repeat profiling. Comparison of individuals living in two regions with different air pollution, however, did not reveal statistically significantly increased number of mutations in the population from the region of poorer environmental conditions, although indicating such tendency.
Trvalý link: http://hdl.handle.net/11104/0198012