Počet záznamů: 1

DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay

  1. 1.
    0360452 - UEM-P 2012 RIV IE eng J - Článek v odborném periodiku
    Topinka, Jan - Rössner ml., Pavel - Milcová, Alena - Schmuczerová, Jana - Švecová, Vlasta - Šrám, Radim
    DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay.
    Toxicology Letters. Roč. 202, č. 3 (2011), s. 186-192 ISSN 0378-4274
    Grant CEP: GA MŠk 2B08005; GA MŽP(CZ) SP/1B3/8/08
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: air pollution * genotoxicity * DNA adducts
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.230, rok: 2011

    The genotoxic acitivity of complex mixtures of organic extracts from urban air particles (PM2.5) collected in various localities of the Czech Republic with different levels of air pollution was compared. As markers of genotoxic potential, DNA adduct levels and oxidative DNA damage (8-oxodG levels) induced by EOMs in an acellular assay of calf thymus DNA coupled with 32P-postlabeling (DNA adducts) and ELISA (8-oxodG) were employed. The results indicate that the industrial emissions prevailing in Ostrava-Bartovice represent a substantially higher genotoxic risk that mostly traffic-related emissions in Ostrava-Poruba. B[a]P and c-PAH contents in EOMs are the most important factors relating to their genotoxic potential.
    Trvalý link: http://hdl.handle.net/11104/0198004