Počet záznamů: 1

Distribution of BODIPY-labelled phosphatidylethanolamines in lipid bilayers exhibiting different curvatures

  1. 1.
    0360229 - UFCH-W 2012 RIV GB eng J - Článek v odborném periodiku
    Šachl, Radek - Mikhalyov, I. - Gretskaya, N. - Olžyńska, Agnieszka - Hof, Martin - Johansson, B.-A.
    Distribution of BODIPY-labelled phosphatidylethanolamines in lipid bilayers exhibiting different curvatures.
    Physical Chemistry Chemical Physics. Roč. 13, č. 24 (2011), s. 11694-11701 ISSN 1463-9076
    Grant CEP: GA ČR GAP208/10/1090; GA MŠk(CZ) LC06063
    Výzkumný záměr: CEZ:AV0Z40400503
    Klíčová slova: BODIPY-labelled phosphatidylethanolamines * lipid bilayers * physical chemistry
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 3.573, rok: 2011

    In this paper we have investigated the behaviour of newly synthesised mono-palmitoyl- and dipalmitoyl-phosphatidylethanolamine probes (abbreviated as mPE and dPE, respectively) labelled in the polar headgroup region by either the FL-BODIPY or the 564/570-BODIPY fluorophore and solubilised in lipid systems that exhibit different curvatures. Because of the bulky BODIPY-groups, the monoacyl-form derivatives have a conic-like shape, whereas that for the diacyl derivatives is rather cylindrical. A careful analysis of time-resolved resonance energy transfer experiments by means of analytical models as well as Monte Carlo simulations shows that the mPE derivatives have a comparable affinity to highly curved bilayer regions (torroidal pores formed by magainin-2 in lipid bilayers, or the rims of discoid bicelles) and to planar bilayer regions (i.e. the flat region of lipid bilayers and bicelles).
    Trvalý link: http://hdl.handle.net/11104/0197828