Počet záznamů: 1

Latent Microsporidial Infection in Immunocompetent Individuals – A Longitudinal Study

  1. 1.
    0360132 - BC-A 2012 RIV US eng J - Článek v odborném periodiku
    Sak, Bohumil - Kváč, Martin - Kučerová, Z. - Květoňová, Dana - Saková, Kamila
    Latent Microsporidial Infection in Immunocompetent Individuals – A Longitudinal Study.
    PLoS Neglected Tropical Diseases. Roč. 5, č. 5 (2011), e1162 ISSN 1935-2735
    Grant CEP: GA AV ČR KJB500960701; GA ČR GP523/07/P117
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: Microsporidia * AIDS * indirect immunofluorescence assay * Encephalitozoon * immunosupression
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 4.716, rok: 2011

    Microsporidia (Fungi) have been repeatedly identified as the cause of opportunistic infections predominantly in immunodeficient individuals such as AIDS patients. However, the global epidemiology of human microsporidiosis is poorly understood and the ability of microsporidia to survive and multiply in immunocompetent hosts remains unsolved. Sera, urine and stool originating from 15 persons (HIV-negative people at risk with occupational exposure to animals, aged 22–56 years, living in the Czech Republic) have been tested by indirect immunofluorescence assay (IFA) for the presence of specific anti-microsporidial antibodies, standard Calcofluor M2R staining for the detection of microsporidian spores in all urine sediments and stool smears and molecular methods for the microsporidial species determination. Our data clearly show that exposure to microsporidia is common and chronic microsporidiosis is not linked to any clinical manifestation in healthy population.
    Trvalý link: http://hdl.handle.net/11104/0197757