Počet záznamů: 1

Synergistic effect of HPMA copolymer-bound doxorubicin and dexamethasone in vivo on mouse lymphomas

  1. 1.
    0359969 - UMCH-V 2012 RIV GB eng J - Článek v odborném periodiku
    Kostková, Hana - Etrych, Tomáš - Říhová, Blanka - Ulbrich, Karel
    Synergistic effect of HPMA copolymer-bound doxorubicin and dexamethasone in vivo on mouse lymphomas.
    Journal of Bioactive and Compatible Polymers. Roč. 26, č. 3 (2011), s. 270-286 ISSN 0883-9115
    Grant CEP: GA AV ČR IAAX00500803; GA AV ČR IAA400500806; GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
    Klíčová slova: HPMA copolymer * doxorubicin * dexamethasone
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.953, rok: 2011

    N-(2-Hydroxypropyl)methacrylamide copolymer—drug conjugates bearing the antiinflammatory and anti-proliferative drug dexamethasone (DEX) and the anti-cancer drug doxorubicin (DOX) bound to either the polymer carrier separately or in combination, were synthesized. Both the in vitro and in vivo anti-cancer activity on mouse B-cell (38C13) and T-cell (EL4) lymphoma was studied. The conjugates were fairly stable in model buffers at pH 7.4, simulating blood pH, and the drug was released by chemical hydrolysis at pH values based on the endosomal and lysosomal environments in the target cells (pH 5—6).Contrary to the treatment with either single drug conjugate, where no significant long-term survival was observed, a synergistic effect of the two drugs was manifested in vivo. Treatment of mice bearing B-cell lymphoma 38C13 formulated as a mixture of both single drug-containing conjugates or a as a conjugate with both drugs in combination gave long-term survivors.
    Trvalý link: http://hdl.handle.net/11104/0006466