Počet záznamů: 1

Astroglial networks scale synaptic activity and plasticity

  1. 1.
    0359930 - UEM-P 2012 RIV US eng J - Článek v odborném periodiku
    Pannasch, U. - Vargová, Lýdia - Reingruber, J. - Ezan, P. - Holcman, D. - Giaume, C. - Syková, Eva - Rouach, N.
    Astroglial networks scale synaptic activity and plasticity.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 108, č. 20 (2011), s. 8467-8472 ISSN 0027-8424
    Grant CEP: GA MŠk(CZ) MEB021140
    Grant ostatní: GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: hippocampus * neuroglial interactions
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 9.681, rok: 2011

    Using mice deficient for connexin 30 and 43, the study show that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. By controlling synaptic strength, connexins play an important role in synaptic plasticity. The results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
    Trvalý link: http://hdl.handle.net/11104/0197610