Počet záznamů: 1

Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat

  1. 1.
    0359902 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Urdzíková, Lucia - Mašínová, Katarína - Vaněček, Václav - Růžička, Jiří - Šedý, Jiří - Syková, Eva - Jendelová, Pavla
    Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat.
    Cytotherapy. Roč. 13, č. 9 (2011), s. 1090-1104 ISSN 1465-3249
    Grant CEP: GA AV ČR IAA500390902; GA MŠk(CZ) LC554
    Grant ostatní: GA MŠk(CZ) 1M0538
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: axonal sprouting * bone marrow mobilization * Flt3 ligand
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.627, rok: 2011

    The aim of this study was to evaluate the effect of G-CSF and/or the Flt3 ligand on functional outcome and tissue regeneration in a rat model of spinal cord injury (SCI). Rats with a balloon-induced compression lesion were injected with G-CSF and/or Flt3 ligand to mobilize bone marrow cells. Behavioral tests, blood counts, morphometric evaluation of the white and gray matter, and histology were performed 5 weeks after SCI.Our results showed, that the mobilization of bone marrow cells by G-CSF, Flt3 ligand and particularly their combination improved the motor and sensory performance of rats with SCI, reduced glial scarring, increased axonal sprouting and spared white and gray matter in the lesion.
    Trvalý link: http://hdl.handle.net/11104/0197593