Počet záznamů: 1

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells

  1. 1.
    0359477 - UZFG-Y 2012 RIV GB eng J - Článek v odborném periodiku
    Šolc, Petr - Schultz, R. M. - Motlík, Jan
    Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells.
    Molecular Human Reproduction. Roč. 16, č. 9 (2010), s. 654-664 ISSN 1360-9947
    Grant CEP: GA ČR(CZ) GC301/09/J036; GA MŠk ME08030
    Grant ostatní: NIH(US) HD22681
    Výzkumný záměr: CEZ:AV0Z50450515
    Klíčová slova: resumption of meiosis * prophase I arrest * oocyte
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.506, rok: 2010

    Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly coupled with regulating cyclin-dependent kinase 1 (CDK1) activity. Prophase I arrest depends on inhibitory phosphorylation of CDK1 and anaphase-promoting complex-(APC-CDH1)-mediated regulation of cyclin B levels. Prophase I arrest is maintained by endogenously produced cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) that in turn phosphorylates (and activates) the nuclear kinase WEE2. In addition, PKA-mediated phosphorylation of the phosphatase CDC25B results in its cytoplasmic retention. The combined effect maintains low levels of CDK1 activity that are not sufficient to initiate resumption of meiosis.
    Trvalý link: http://hdl.handle.net/11104/0197261