Počet záznamů: 1

New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations

  1. 1.
    0359458 - UMCH-V 2012 RIV GB eng J - Článek v odborném periodiku
    Brus, Jiří - Urbanová, Martina - Šeděnková, Ivana - Brusová, H.
    New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations.
    International Journal of Pharmaceutics. Roč. 409, 1/2 (2011), s. 62-74 ISSN 0378-5173
    Grant CEP: GA MŠk 2B08021
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: 19F MAS NMR * factor analysis * polymorphism
    Kód oboru RIV: CB - Analytická chemie, separace
    Impakt faktor: 3.350, rok: 2011

    Despite recent advances in solid-state NMR, the structural characterization of amorphous pharmaceuticals (APIs) in solid dosage forms continues to be a monumental challenge. To circumvent complications following from low concentrations of APIs in tablet formulations, we propose a new time-saving procedure based on chemometric approach: factor analysis of 19F MAS NMR spectra. Capability of the proposed method is demonstrated on atorvastatin – a typical representative of fluorinated pharmaceutical substances exhibiting extensive polymorphism. Applying the factor analysis on the recorded 19F MAS NMR spectra, unique parameters for every sample were derived. In this way every solid form of atorvastatin was characterized and clearly distinguishable even among various amorphous and disordered forms. Reliability of the proposed method was examined by comparing with other techniques and perspectives to obtain structural view on variability of amorphous products are also discussed.
    Trvalý link: http://hdl.handle.net/11104/0197244