Počet záznamů: 1

Hydrazone-based hydrogel hydrolytically degradable in acidic environment

  1. 1.
    0359454 - UMCH-V 2012 RIV NL eng J - Článek v odborném periodiku
    Vetrík, Miroslav - Přádný, Martin - Hrubý, Martin - Michálek, Jiří
    Hydrazone-based hydrogel hydrolytically degradable in acidic environment.
    Polymer Degradation and Stability. Roč. 96, č. 5 (2011), s. 756-759 ISSN 0141-3910
    Grant CEP: GA ČR GAP108/10/1560; GA ČR GPP207/10/P054; GA MŠk 1M0538
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: polymer * hydrogel * hydrazone bond
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.769, rok: 2011

    We describe the synthesis of new crosslinker N′-{3-[2-(4-{2-[3-(methacryloylamino) propanoyl] hydrazono}cyclohexyliden)hydrazino]-3-oxopropyl}-2-methylacrylamide, which is stable at physiological pH, but is hydrolytically cleaved in acidic pH. Study of acid hydrolysis showed that the crosslinker is hydrolyzed into two N′-(3-hydrazino-3-oxopropyl)-2-methylacrylamide molecules and one 1,4-cyclohexanedione molecule. Hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with this crosslinker were prepared and their degradation rate was studied as a function of pH (in the range of pH 1.5–7.4). The hydrogel is cleaved within 8–27 days at pH between 1.5 and 6 and is stable at pH 7.4 making it promising for the construction of oesophageal stents.
    Trvalý link: http://hdl.handle.net/11104/0197240