Počet záznamů: 1

Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis

  1. 1.
    0359445 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Pravenec, Michal - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, J. - Maxová, M. - Kazdová, L. - Seidman, J. G. - Seidman, Ch. E. - Eminaga, S. - Gorham, J. - Wang, J. - Kurtz, T. W.
    Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.
    Physiological Genomics. Roč. 43, č. 7 (2011), s. 372-379 ISSN 1094-8341
    Grant CEP: GA MŠk(CZ) ME08006; GA MŠk(CZ) 1M0510; GA AV ČR(CZ) IAA500110805; GA MZd(CZ) NS9759
    Grant ostatní:Fondation Leducq(FR) 06CVD03
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: transgenic rat * adipose tissue * insulin resistance * autocrine effects
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.735, rok: 2011

    We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue
    Trvalý link: http://hdl.handle.net/11104/0197234