Počet záznamů: 1

Hyaluronan minimizes effects of UV irradiation on human keratinocytes

  1. 1.
    0359410 - BFU-R 2012 RIV DE eng J - Článek v odborném periodiku
    Hašová, M. - Crhák, Tomáš - Šafaříková, Barbora - Dvořáková, J. - Muthný, T. - Velebný, V. - Kubala, Lukáš
    Hyaluronan minimizes effects of UV irradiation on human keratinocytes.
    Archives of Dermatological Research. Roč. 303, č. 4 (2011), s. 277-284 ISSN 0340-3696
    Grant CEP: GA ČR(CZ) GA305/08/1704
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: hyaluronan * keratinocyte * ultraviolet light
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.279, rok: 2011

    Exposure to ultraviolet (UV) irradiation has detrimental effects on skin accompanied by the increased metabolism of hyaluronan (HA). Immortalized human keratinocytes (HaCaT) were irradiated by a single dose of UVB and immediately treated with HA for 6 and 24 h. The expressions of HA synthase-3 and hyaluronidase-3 were not significantly odulated by UV irradiation. In contrast, HA significantly suppressed UVB-induced proinflammatory cytokine release including interleukin-6 and interleukin-8.
    Trvalý link: http://hdl.handle.net/11104/0197206