Počet záznamů: 1

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, Fe-57 Mossbauer), theoretical, and biological activity studies

  1. 1.
    0359316 - UEB-Q 2011 RIV US eng J - Článek v odborném periodiku
    Trávníček, Zdeněk - Popa, Igor - Čajan, Michal - Zbořil, R. - Kryštof, Vladimír - Mikulík, J.
    The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, Fe-57 Mossbauer), theoretical, and biological activity studies.
    Journal of Inorganic Biochemistry. Roč. 104, č. 4 (2010), s. 405-417 ISSN 0162-0134
    Grant CEP: GA MŠk 1M0512; GA ČR GA301/08/1649
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Iron(III) complexes * 57Fe Mössbauer spectroscopy * CDK inhibition
    Kód oboru RIV: CA - Anorganická chemie
    Impakt faktor: 3.317, rok: 2010

    The first FeIII complexes 1–6 with cyclin-dependent kinase (CDK) inhibitors of the type [Fe(Ln)Cl3]•nH2O (n = 0 for 1, 1 for 2, 2 for 3–6; L1–L6 = C2- and phenyl-substituted CDK inhibitors derived from 6-benzylamino-9-isopropylpurine), have been synthesized and characterized by elemental analysis, IR, 57Fe Mössbauer, 1H and 13C NMR, and ES+ mass spectroscopies, conductivity and magnetic susceptibility measurements, and thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The study revealed that the compounds are mononuclear, tetrahedral high-spin (S = 5/2) FeIII complexes with an admixture of an S = 3/2 spin state originating probably from five-coordinated FeIII ions either connecting with a bidentate coordination mode of the CDK inhibitor ligand or relating to the possibility that one crystal water molecule enters the coordination sphere of the central atom in a portion of molecules of the appropriate complex.
    Trvalý link: http://hdl.handle.net/11104/0198841