Počet záznamů: 1

Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles

  1. 1.
    0359268 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Volkov, E. M. - Nurullin, L. F. - Volkov, M. E. - Nikolsky, E. E. - Vyskočil, František
    Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles.
    Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. Roč. 158, č. 4 (2011), s. 520-524 ISSN 1095-6433
    Grant CEP: GA AV ČR(CZ) IAA500110905; GA ČR GA202/09/0806
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: GABA * acetylcholine * atropine
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 2.235, rok: 2011

    This work was aimed to identify the action of several ion channel and pump inhibitors as well as nicotinic, GABAergic, purinergic and serotoninergic drugs on the resting membrane potential (RMP) and assess the role of cholinergic and GABAergic sensitivity in earthworm muscle electrogenesis. . The long-term application of CCh depolarizes the RMP primarily by inhibiting the Na+/K+-ATPase. The muscle membrane also contains A and B type GABA binding sites, the activation of which increases the RMP at the expense of increasing the action of ouabain- and Cl- -sensitive electrogenic pumps
    Trvalý link: http://hdl.handle.net/11104/0197081