Počet záznamů: 1  

The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases

  1. 1.
    0359135 - ÚOCHB 2012 RIV GB eng J - Článek v odborném periodiku
    Kovačková, Soňa - Dračínský, Martin - Rejman, Dominik
    The synthesis of piperidine nucleoside analogs-a comparison of several methods to access the introduction of nucleobases.
    Tetrahedron. Roč. 67, č. 7 (2011), s. 1485-1500. ISSN 0040-4020. E-ISSN 1464-5416
    Grant CEP: GA MŠMT 2B06065; GA MZd NR9138; GA MŠMT(CZ) LC06077
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: piperidine derivatives * nucleoside analogs * nucleobase * proline
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.025, rok: 2011

    This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found.
    Trvalý link: http://hdl.handle.net/11104/0196975

     
     
Počet záznamů: 1  

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