Počet záznamů: 1

Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats

  1. 1.
    0358912 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Borchert, Gudrun H. - Yang, Ch. - Kolář, František
    Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats.
    American Journal of Physiology-Heart and Circulatory Physiology. Roč. 300, č. 2 (2011), H507-H513 ISSN 0363-6135
    Grant CEP: GA ČR(CZ) GA305/07/1008; GA AV ČR IAA500110804
    Klíčová slova: chronic hypoxia * ventricular myocytes * metabolic inhibition * cell viability * potassium channels
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 3.708, rok: 2011

    Chronic hypoxia reduced glycosylation level of the beta-1 regulatory subunit of the cardiac mitochondrial large-conductance calcium-activated potassium channels (BK). Ventricular myocytes isolated from chronically hypoxic rats retained the improved resistance against injury caused by simulated ischemia/reperfusion. The blunting effect of paxilline (BK inhibitor) and the absence of additive protection by NS-1619 (BK opener) suggest that chronic hypoxia leads to the activation of these channels, which contribute to the protective mechanism
    Trvalý link: http://hdl.handle.net/11104/0196821