Počet záznamů: 1

The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

  1. 1.
    0358792 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Ambrožová, Gabriela - Pekarová, Michaela - Lojek, Antonín
    The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages.
    Toxicology in Vitro. Roč. 25, č. 1 (2011), s. 145-152 ISSN 0887-2333
    Grant CEP: GA MŠk(CZ) OC08058; GA ČR(CZ) GA524/08/1753
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: lipid peroxidation products * reactive oxygen species * nitric oxide
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.775, rok: 2011

    The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) - acrolein, 4-hydroxynonenal, and malondialdehyde - on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acrolein and 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulation of reactive species formation.
    Trvalý link: http://hdl.handle.net/11104/0196729