Počet záznamů: 1

Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery

  1. 1.
    0358505 - UMCH-V 2012 RIV US eng J - Článek v odborném periodiku
    Angelova, A. - Angelov, Borislav - Mutafchieva, R. - Lesieur, S. - Couvreur, P.
    Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery.
    Accounts of Chemical Research. Roč. 44, č. 2 (2011), s. 147-156 ISSN 0001-4842
    Grant CEP: GA ČR GA202/09/2078; GA ČR GAP208/10/1600
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: lipid-water phases * liquid crystals * multicompartment lipid nanostructures
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 21.640, rok: 2011

    Lipids and lipopolymers self-assembled into biocompatible nano and mesostructured functional materials offer many potential applications in medicine and diagnostics. In this Account, it is demonstrated how high-resolution structural investigations of bicontinuous cubic templates made from lyotropic thermosensitive liquid-crystalline (LC) materials have initiated the development of innovative lipidopolymeric self-assembled nanocarriers. Such structures have tunable nanochannel sizes, morphologies, and hierarchical inner organizations and provide potential vehicles for the predictable loading and release of therapeutic proteins, peptides, or nucleic acids. This Account shows that structural studies of swelling of bicontinuous cubic lipid/water phases are essential for overcoming the nanoscale constraints for encapsulation of large therapeutic molecules in multicompartment lipid carriers.
    Trvalý link: http://hdl.handle.net/11104/0196529