Počet záznamů: 1

Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

  1. 1.
    0358349 - BC-A 2012 RIV US eng J - Článek v odborném periodiku
    Chmelař, Jindřich - Oliveira, C. J. - Řezáčová, Pavlína - Francischetti, I.M.B. - Kovářová, Zuzana - Pejler, G. - Kopáček, Petr - Ribeiro, J.M.C. - Mareš, Michael - Kopecký, Jan - Kotsyfakis, Michalis
    Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
    Blood. Roč. 117, č. 2 (2011), s. 736-744 ISSN 0006-4971
    Grant CEP: GA AV ČR IAA600960811; GA MŠk(CZ) LC06009; GA ČR(CZ) GAP207/10/2183
    Výzkumný záměr: CEZ:AV0Z60220518; CEZ:AV0Z40550506
    Klíčová slova: parasite serpin * IRS-2 * tick * Ixodes ricinus * platelet aggregation * inflammation * cathepsin G * chymase
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 9.898, rok: 2011

    A protein with antiinflammatory and anti-platelet effect was identified. It was named IRS-2 (Ixodes ricinus serpin – 2). It belongs into the group of serpins – inhibitors of serine proteases and the mode of action of IRS-2 derives from its inhibitory activity against cathepsin G and mast cell chymase. Antiinflammatory activity was shown using paw edema experiment with mice. IRS-2 inhibited specifically only cathepsin G and thrombin induced platelet aggregation.
    Trvalý link: http://hdl.handle.net/11104/0196424