Počet záznamů: 1

Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway

  1. 1.
    0357770 - BFU-R 2011 RIV GB eng J - Článek v odborném periodiku
    Vondálová Blanářová, Olga - Jelínková, Iva - Szoor, A. - Skender, Belma - Souček, Karel - Horváth, Viktor - Vaculová, Alena - Anděra, Ladislav - Sova, P. - Szollosi, J. - Hofmanová, Jiřina - Vereb, G. - Kozubík, Alois
    Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
    Carcinogenesis. Roč. 32, č. 1 (2011), s. 42-51 ISSN 0143-3334
    Grant CEP: GA ČR(CZ) GA301/07/1557; GA MZd NS9600
    Grant ostatní: GA ČR(CZ) GD303/09/H048
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50520514
    Klíčová slova: TRAIL * platinum complexes * apoptosis
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.702, rok: 2011

    Platinum complexes LA-12 and cisplatin enhanced TRAIL-induced apoptosis in colon and prostate cancer cells. They increased surface expression of DR5 receptor for TRAIL, which has been shown to be crucial for induction of apoptosis. Moreover, LA-12 and cisplatin mediated translocation of TRAIL receptors DR4 and DR5 to lipid rafts and enhanced internalization of TRAIL. These events modulated early steps of TRAIL, signaling and may contribute to induction of apoptosis.
    Trvalý link: http://hdl.handle.net/11104/0195967