Počet záznamů: 1

Determination of Substitution Sites in Monosubstituted Five-Membered Aromatic Heterocycles

  1. 1.
    0357015 - UCHP-M 2012 RIV GB eng J - Článek v odborném periodiku
    Schraml, Jan - Kubec, R. - Kučerová, P.
    Determination of Substitution Sites in Monosubstituted Five-Membered Aromatic Heterocycles.
    Magnetic Resonance in Chemistry. Roč. 49, č. 3 (2011), s. 147-150 ISSN 0749-1581
    Grant CEP: GA AV ČR IAA400720706
    Výzkumný záměr: CEZ:AV0Z40720504
    Klíčová slova: pyrrole * 13c nmr * inadequate
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 1.437, rok: 2011

    Similar magnitudes of proton–proton couplings across three, four, and five bonds and proton–carbon couplings across two and three bonds combined with difficult to predict substituent effects make the results of an indiscriminate use of routine techniques for substitution sitedetermination in C-monosubstituted five-memberedheteroaromatics suspect. As demonstrated on two examples of natural products, the use of 1,1-ADEQUATE leads to unambiguous substitution site determination lending thus further support to suggested inclusion of 1,1-ADEQUATE data into computer-assisted structure elucidation (CASE) protocols.
    Trvalý link: http://hdl.handle.net/11104/0195389