Počet záznamů: 1

Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro

  1. 1.
    0356880 - BFU-R 2011 RIV SE eng J - Článek v odborném periodiku
    Perečko, T. - Drábiková, K. - Račková, L. - Číž, Milan - Podborská, Martina - Lojek, Antonín - Harmatha, Juraj - Šmidrkal, J. - Nosál, R. - Jančinová, V.
    Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.
    Neuroendocrinology Letters. Roč. 31, č. 2 (2010), s. 84-90 ISSN 0172-780X
    Grant CEP: GA MŠk(CZ) OC08058; GA MŠk(CZ) MEB0810013
    Grant ostatní: GA ČR(CZ) GA203/07/1227
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z40550506
    Klíčová slova: pterostilbene * reactive oxygen species * neutrophils
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 1.621, rok: 2010

    Pterostilbene, an analog of resveratrol, was identified as a good natural antioxidant compound. However, reducing the oxidative burst of human neutrophils during their activation in vitro with pterostilbene does not include protein kinase C phosphorylation pathway. Pterostilbene showed dose dependent activation/inhibition of caspase-3 enzyme activity.
    Trvalý link: http://hdl.handle.net/11104/0195288