Počet záznamů: 1

Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity

  1. 1.
    0356878 - BFU-R 2011 RIV SE eng J - Článek v odborném periodiku
    Drábiková, K. - Perečko, T. - Nosál, R. - Račková, L. - Ambrožová, Gabriela - Lojek, Antonín - Šmidrkal, J. - Harmatha, Juraj - Jančinová, V.
    Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.
    Neuroendocrinology Letters. Roč. 31, č. 2 (2010), s. 73-78 ISSN 0172-780X
    Grant CEP: GA MŠk(CZ) MEB0810013
    Grant ostatní: GA ČR(CZ) GA203/07/1227
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z40550506
    Klíčová slova: reactive species * phagocytosis * coumarin
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 1.621, rok: 2010

    Synthetic phenylcoumarin derivatives HHC (7-hydroxy-3-(4'-hydroxyphenyl) coumarin) and HHDC (7-hydroxy-3-(4'-hydroxyphenyl)-3,4-dihydrocoumarin) can affect ROS generation in human neutrophils and NO production by RAW 264.7 macrophages. The obtained results highlighted the different effects of HHC and HHDC on fagocyte functions, which might be due to their diverse free radical scavenging properties and lipophilicity features.
    Trvalý link: http://hdl.handle.net/11104/0195286