Počet záznamů: 1

Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines

  1. 1.
    0356673 - UZFG-Y 2011 RIV DE eng J - Článek v odborném periodiku
    Skalníková, Helena - Motlík, Jan - Gadher, S. J. - Kovářová, Hana
    Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines.
    Proteomics. Roč. 11, - (2011), s. 691-708 ISSN 1615-9853
    Grant CEP: GA MŠk 1M0538; GA MŠk(CZ) ME10044
    Výzkumný záměr: CEZ:AV0Z50450515
    Klíčová slova: cell biology * conditioned media * cytokine
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.505, rok: 2011

    Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein hormones, immunoregulatory cytokines, chemokines or other bioactive molecules that have a direct impact on target cell phenotype. Stem cells of mesenchymal, adipose, neural and embryonic origin, fibroblast feeder cells as well as primary isolates of astrocytes, endothelial and muscle cells have recently become targets of intensive secretome profiling with the search for proteins regulating cell survival, proliferation, differentiation or inflammatory response. Recent advances and challenges of the stem cell and primary cell secretome analysis together with the most relevant results are discussed in this review.
    Trvalý link: http://hdl.handle.net/11104/0195133