Počet záznamů: 1

Functional connectivity in resting-state fMRI: Is linear correlation sufficient?

  1. 1.
    0356655 - UIVT-O 2011 RIV US eng J - Článek v odborném periodiku
    Hlinka, Jaroslav - Paluš, Milan - Vejmelka, Martin - Mantini, D. - Corbetta, M.
    Functional connectivity in resting-state fMRI: Is linear correlation sufficient?.
    Neuroimage. Roč. 54, č. 3 (2011), s. 2218-2225 ISSN 1053-8119
    Grant CEP: GA MŠk 7E08027
    GRANT EU: European Commission(XE) 200728 - BRAINSYNC
    Výzkumný záměr: CEZ:AV0Z10300504
    Klíčová slova: fMRI * functional connectivity * Gaussianity * nonlinearity * correlation * mutual information
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 5.895, rok: 2011

    Functional connectivity (FC) analysis is a prominent approach to analyzing fMRI data, especially acquired in resting state. The commonly used linear correlation bears an implicit assumption of Gaussianity of the dependence structure. To assess the suitability of linear correlation and the general potential of nonlinear FC measures, we present a framework for testing and estimating the deviation from Gaussianity by comparing mutual information in the data and its Gaussianized counterpart. We apply this method to 24 sessions of human resting state fMRI. While the group-level tests confirmed non-Gaussianity in the FC, the quantitative assessment revealed that the portion of mutual information neglected by linear correlation is relatively minor - on average only about 5% of the total mutual information. We conclude that for this type of data, practical relevance of nonlinear methods trying to improve over linear correlation is limited by the fact that the data are almost Gaussian.
    Trvalý link: http://hdl.handle.net/11104/0195122
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