Počet záznamů: 1

[2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes

  1. 1.
    0356369 - UOCHB-X 2011 RIV JP eng J - Článek v odborném periodiku
    Opekar, S. - Turek, P. - Pohl, Radek - Klepetářová, Blanka - Votruba, Ivan - Hocek, Michal - Kotora, M.
    [2+2+2]-Cocyclotrimerization of 6-Alkynyl-7-benzylpurines with alpha, omega-Diynes.
    Heterocycles. Roč. 82, č. 1 (2010), s. 895-907 ISSN 0385-5414
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: cyclotrimerization * purine * alkyne * nickel * catalysis
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.093, rok: 2010

    6-Alkynyl-7-benzylpurines were prepared by the Sonogashira reaction from 6-chloro-7-benzylpurines and terminal alkynes. The prepared alkynylpurines were cyclotrimerized with various 1,6-diynes in the presence of Ni(cod)2/2PPh3 catalytic system into the corresponding 6-aryl-7-benzylpurines under ambient conditions. The prepared 6-alkynyl- and 6-aryl-7-benzylpurines were tested for cytostatic activity.
    Trvalý link: http://hdl.handle.net/11104/0194908